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A good example is a review published in 2003 in Endocrine Reviews , in which the authors note the importance of [growth hormone] and IGF systems in normal skin homeostasis. They specifically mention the role that growth hormone plays in collagen synthesis and the effect that IGF has on skin cell proliferation

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These compounds are responsible for many of the health benefits associated with ginseng, a popular herbal remedy used in traditional Chinese medicine for thousands of years